patient_id stringlengths 6 6 | gene_marker stringlengths 3 6 | mutation_type stringlengths 4 13 | drug_molecule stringlengths 6 13 | binding_energy_kcal float64 -12.4 -6.22 | cellular_viability_pct float64 2.5 78.5 | toxicity_index float64 0.04 0.3 | clinical_efficacy stringclasses 4 values | dosage_mg_kg float64 1.5 20 | metabolic_rate stringclasses 3 values |
|---|---|---|---|---|---|---|---|---|---|
PM-901 | EGFR | L858R | Osimertinib | -9.42 | 12.5 | 0.08 | High | 5 | Normal |
PM-902 | BRAF | V600E | Vemurafenib | -8.85 | 22.1 | 0.15 | High | 20 | Fast |
PM-903 | ALK | Fusion | Crizotinib | -7.92 | 45.8 | 0.12 | Moderate | 15 | Normal |
PM-904 | KRAS | G12C | Sotorasib | -9.15 | 18.4 | 0.22 | High | 10 | Slow |
PM-905 | HER2 | Amplification | Trastuzumab | -11.2 | 5.2 | 0.05 | Exceptional | 8 | Normal |
PM-906 | BRCA1 | Frameshift | Olaparib | -8.44 | 32.7 | 0.18 | Moderate | 4.5 | Normal |
PM-907 | PIK3CA | H1047R | Alpelisib | -7.12 | 58.4 | 0.25 | Low | 12 | Fast |
PM-908 | MET | Exon14_Skip | Tepotinib | -8.98 | 20.5 | 0.11 | High | 7.5 | Normal |
PM-909 | FGFR2 | Rearrangement | Pemigatinib | -8.21 | 38.2 | 0.14 | Moderate | 10 | Slow |
PM-910 | NTRK1 | Fusion | Larotrectinib | -10.5 | 8.1 | 0.06 | High | 5 | Normal |
PM-911 | EGFR | T790M | Osimertinib | -9.22 | 14.8 | 0.09 | High | 5 | Normal |
PM-912 | BRAF | V600K | Dabrafenib | -8.72 | 25.4 | 0.16 | High | 20 | Fast |
PM-913 | KIT | Exon11_Mut | Imatinib | -9.88 | 10.2 | 0.1 | Exceptional | 15 | Normal |
PM-914 | RET | Fusion | Selpercatinib | -9.55 | 11.4 | 0.07 | High | 5 | Normal |
PM-915 | ROS1 | Fusion | Entrectinib | -8.66 | 28.9 | 0.13 | Moderate | 12 | Slow |
PM-916 | PD-L1 | High_Expr | Pembrolizumab | -12.4 | 2.5 | 0.04 | High | 2 | Normal |
PM-917 | IDH1 | R132H | Ivosidenib | -7.85 | 42.1 | 0.19 | Moderate | 10 | Normal |
PM-918 | TP53 | Missense | Ad-p53 | -6.22 | 78.5 | 0.3 | Low | 1.5 | Fast |
PM-919 | ESR1 | Y537S | Elacestrant | -8.15 | 35.4 | 0.17 | Moderate | 5 | Normal |
PM-920 | PTEN | Deletion | Everolimus | -7.45 | 52.1 | 0.21 | Low | 10 | Slow |
PM-921 | EGFR | L858R | Gefitinib | -8.55 | 28.2 | 0.12 | Moderate | 5 | Normal |
PM-922 | BRAF | V600E | Encorafenib | -9.02 | 19.5 | 0.14 | High | 20 | Fast |
PM-923 | ALK | L1196M | Lorlatinib | -9.74 | 10.8 | 0.11 | High | 10 | Normal |
PM-924 | KRAS | G12D | MRTX1133 | -8.88 | 24.1 | 0.2 | Moderate | 12 | Slow |
PM-925 | HER2 | Mutation | Tucatinib | -10.1 | 9.5 | 0.08 | High | 8 | Normal |
PM-926 | BRCA2 | Nonsense | Talazoparib | -8.92 | 21.8 | 0.15 | High | 4.5 | Normal |
PM-927 | PIK3CA | E545K | Copanlisib | -7.58 | 50.4 | 0.22 | Low | 12 | Fast |
PM-928 | MET | Amplification | Capmatinib | -9.35 | 15.2 | 0.1 | High | 7.5 | Normal |
PM-929 | FGFR3 | S249C | Erdafitinib | -8.48 | 30.5 | 0.16 | Moderate | 10 | Slow |
PM-930 | NTRK3 | Fusion | Larotrectinib | -10.7 | 7.2 | 0.05 | High | 5 | Normal |
PM-931 | EGFR | Exon19_Del | Afatinib | -9.1 | 16.5 | 0.13 | High | 5 | Normal |
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