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30.1M
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["TREATS(Paclitaxel
|
Non_Small_Cell_Lung_Cancer)"
|
TREATS(Carboplatin,Non_Small_Cell_Lung_Cancer)
|
REDUCES(Paclitaxel,Tumor_Volume)]
|
A Phase II Study of Carboplatin and Paclitaxel
| 30,123,456
|
S001
|
Treatment with 'Paclitaxel' and 'Carboplatin' led to a reduction in 'Tumor_Volume' in 'Non_Small_Cell_Lung_Cancer'.
|
["Paclitaxel"
|
Carboplatin
|
Tumor_Volume
|
Non_Small_Cell_Lung_Cancer]
|
["CAUSES(APOE4
|
Alzheimer's_Disease)"
|
ASSOCIATED_WITH(APOE4,Amyloid_Beta)]
|
Genetic Risk Factors in Neurodegenerative Disorders
|
30123457
| null |
S002
|
The 'APOE4' allele is a known 'Risk_Factor' for 'Alzheimer's_Disease', influencing 'Amyloid_Beta' deposition.
|
["APOE4"
|
Risk_Factor
|
Alzheimer's_Disease
|
Amyloid_Beta]
|
Type_2_Diabetes)"
|
REGULATES(Metformin,Hepatic_Glucose_Output)]
|
Metformin's Mechanism of Action
|
30123458
| null | null |
S003
|
'Metformin' is often prescribed to manage 'Type_2_Diabetes', primarily by reducing 'Hepatic_Glucose_Output'.
|
["Metformin"
|
Type_2_Diabetes
|
Hepatic_Glucose_Output]
|
["TREATS(Metformin
|
Cetuximab)"
|
TARGETS(Cetuximab,EGFR)]
|
EGFR Status and Anti-EGFR Therapy
|
30123459
| null | null |
S004
|
High expression of 'EGFR' suggests resistance to 'Cetuximab' in 'Colorectal_Cancer' patients.
|
["EGFR"
|
Cetuximab
|
Colorectal_Cancer]
|
["INDICATOR_OF_RESISTANCE(EGFR
|
Leukemia)"
|
IS_A(Myeloid_Leukemia,Leukemia)]
|
Occupational Exposure and Hematologic Malignancies
|
30123460
| null | null |
S005
|
Exposure to 'Formaldehyde' is linked to increased risk of 'Leukemia', especially the 'Myeloid_Leukemia' subtype.
|
["Formaldehyde"
|
Leukemia
|
Myeloid_Leukemia]
|
["CAUSES(Formaldehyde
|
["INHIBITS(Bevacizumab
|
VEGF)"
|
REGULATES(Bevacizumab,Angiogenesis)]
|
Anti-Angiogenic Strategies in Oncology
|
30123461
| null |
S006
|
Inhibition of 'VEGF' with 'Bevacizumab' is a strategy to limit 'Angiogenesis' in various 'Solid_Tumors'.
|
["VEGF"
|
Bevacizumab
|
Angiogenesis
|
Solid_Tumors]
|
Bone_Density)"
|
CAUSES(Vitamin_D,Osteoporosis)]
|
The Role of Vitamin D in Skeletal Health
|
30123462
| null | null |
S007
|
A deficiency in 'Vitamin_D' is correlated with lower 'Bone_Density' and increased risk of 'Osteoporosis'.
|
["Vitamin_D"
|
Bone_Density
|
Osteoporosis]
|
["ASSOCIATED_WITH(Vitamin_D
|
Breast_Cancer)"
|
CAUSES(BRCA1,Ovarian_Cancer)]
|
Hereditary Cancer Syndromes
|
30123463
| null | null |
S008
|
Mutations in the 'BRCA1' gene significantly increase susceptibility to 'Breast_Cancer' and 'Ovarian_Cancer'.
|
["BRCA1"
|
Breast_Cancer
|
Ovarian_Cancer]
|
["CAUSES(BRCA1
|
["IS_A(Fentanyl
|
Opioid_Analgesic)"
|
TARGETS(Fentanyl,Mu_Receptors)]
|
Pharmacology of Synthetic Opioids
|
30123464
| null |
S009
|
'Fentanyl' is a potent 'Opioid_Analgesic' primarily acting on 'Mu_Receptors' in the 'Central_Nervous_System'.
|
["Fentanyl"
|
Opioid_Analgesic
|
Mu_Receptors
|
Central_Nervous_System]
|
Influenza_Virus)"
|
CAUSES(H1N1,Pandemic)]
|
Epidemiology of 2009 H1N1
|
30123465
| null | null |
S010
|
The 'H1N1' virus, a type of 'Influenza_Virus', caused a global 'Pandemic' in 2009.
|
["H1N1"
|
Influenza_Virus
|
Pandemic]
|
["IS_A(H1N1
|
Angiotensin_II_Receptor_Blocker)"
|
TREATS(Losartan,Hypertension)]
|
ARBs in Cardiovascular Medicine
|
30123466
| null | null |
S011
|
'Losartan' is an 'Angiotensin_II_Receptor_Blocker' used for managing 'Hypertension'.
|
["Losartan"
|
Angiotensin_II_Receptor_Blocker
|
Hypertension]
|
["IS_A(Losartan
|
Platelet_Aggregation)"
|
PREVENTS(Aspirin,Myocardial_Infarction)]
|
Antiplatelet Therapy Guidelines
|
30123467
| null | null |
S012
|
'Aspirin' inhibits 'Platelet_Aggregation' and is crucial for preventing 'Myocardial_Infarction'.
|
["Aspirin"
|
Platelet_Aggregation
|
Myocardial_Infarction]
|
["INHIBITS(Aspirin
|
Muscle_Paralysis)"
|
REGULATES(Botulinum_Toxin,Acetylcholine)]
|
Mechanisms of Neurotoxin Action
|
30123468
| null | null |
S013
|
The neurotoxin 'Botulinum_Toxin' causes 'Muscle_Paralysis' by blocking 'Acetylcholine' release.
|
["Botulinum_Toxin"
|
Muscle_Paralysis
|
Acetylcholine]
|
["CAUSES(Botulinum_Toxin
|
CRP as an Inflammatory Marker
|
30123469
| null | null | null | null |
S014
|
Elevated levels of 'C-Reactive_Protein' are a biomarker for systemic 'Inflammation'.
|
["C-Reactive_Protein"
|
Inflammation]
|
["INDICATOR_OF(C-Reactive_Protein
|
Inflammation)"]
|
Brain_Cancer)"
|
TREATS(Temozolomide,Glioblastoma)]
|
Standard Treatment for Glioblastoma
|
30123470
| null | null |
S015
|
'Glioblastoma' is the most aggressive form of 'Brain_Cancer', often treated with 'Temozolomide'.
|
["Glioblastoma"
|
Brain_Cancer
|
Temozolomide]
|
["IS_A(Glioblastoma
|
Sirtuin_Activity)"
|
ASSOCIATED_WITH(Resveratrol,Cellular_Aging)]
|
Nutraceuticals and Longevity
|
30123471
| null | null |
S016
|
Research suggests 'Resveratrol' may modulate 'Sirtuin_Activity', impacting 'Cellular_Aging'.
|
["Resveratrol"
|
Sirtuin_Activity
|
Cellular_Aging]
|
["MODULATES(Resveratrol
|
CAUSED_BY(Measles,Morbillivirus)]
|
Global Eradication of Measles
|
30123472
| null | null | null |
S017
|
Vaccination against 'Measles' provides robust protection against the highly contagious 'Morbillivirus'.
|
["Measles"
|
Morbillivirus]
|
["PREVENTS(Vaccination
|
Measles)"
|
["TARGETS(Dupilumab
|
IL-4)"
|
TREATS(Dupilumab,Atopic_Dermatitis)]
|
Biologics in Dermatology
|
30123473
| null |
S018
|
'Dupilumab' is a monoclonal antibody targeting 'IL-4' and 'IL-13' for the treatment of 'Atopic_Dermatitis'.
|
["Dupilumab"
|
IL-4
|
IL-13
|
Atopic_Dermatitis]
|
Basal_Cell_Carcinoma)"
|
IS_A(Basal_Cell_Carcinoma,Skin_Cancer)]
|
Photocarcinogenesis Mechanisms
|
30123474
| null | null |
S019
|
Chronic exposure to 'UV_Radiation' is the primary cause of 'Basal_Cell_Carcinoma', a type of 'Skin_Cancer'.
|
["UV_Radiation"
|
Basal_Cell_Carcinoma
|
Skin_Cancer]
|
["CAUSES(UV_Radiation
|
Pharmacogenomics of Opioids
|
30123475
| null | null | null | null |
S020
|
Genetic variations in 'CYP2D6' affect the metabolism of 'Codeine', influencing its therapeutic effect.
|
["CYP2D6"
|
Codeine]
|
["REGULATES(CYP2D6
|
Codeine)"]
|
Microcephaly)"
|
TARGETS(Zika_Virus,Fetus)]
|
Congenital Zika Syndrome
|
30123476
| null | null |
S021
|
The 'Zika_Virus' infection in pregnant women can cause 'Microcephaly' in the developing 'Fetus'.
|
["Zika_Virus"
|
Microcephaly
|
Fetus]
|
["CAUSES(Zika_Virus
|
["IS_A(Ibuprofen
|
NSAID)"
|
TREATS(Ibuprofen,Pain_Relief)
|
TREATS(Ibuprofen,Fever)]
|
Mechanism of Action of NSAIDs
| 30,123,477
|
S022
|
'Ibuprofen' is a common 'NSAID' used for 'Pain_Relief' and reducing 'Fever'.
|
["Ibuprofen"
|
NSAID
|
Pain_Relief
|
Fever]
|
Parkinson's_Disease)"
|
LOCATION(Dopamine,Substantia_Nigra)]
|
Neurochemistry of Movement Disorders
|
30123478
| null | null |
S023
|
Depletion of 'Dopamine' in the 'Substantia_Nigra' is characteristic of 'Parkinson's_Disease'.
|
["Dopamine"
|
Substantia_Nigra
|
Parkinson's_Disease]
|
["ASSOCIATED_WITH(Dopamine
|
PD-1)"
|
TREATS(Pembrolizumab,Melanoma)]
|
Immune Checkpoint Blockade Therapy
|
30123479
| null | null |
S024
|
Targeting 'PD-1' with 'Pembrolizumab' has shown efficacy in treating 'Melanoma'.
|
["PD-1"
|
Pembrolizumab
|
Melanoma]
|
["TARGETS(Pembrolizumab
|
["IS_A(Type_1_Diabetes
|
Autoimmune_Disease)"
|
LOCATION(Beta_Cells,Pancreas)]
|
Immunology of Type 1 Diabetes
|
30123480
| null |
S025
|
'Type_1_Diabetes' is an 'Autoimmune_Disease' resulting in the destruction of 'Beta_Cells' in the 'Pancreas'.
|
["Type_1_Diabetes"
|
Autoimmune_Disease
|
Beta_Cells
|
Pancreas]
|
Anticoagulant)"
|
INHIBITS(Warfarin,Vitamin_K)]
|
Oral Anticoagulation Therapy
|
30123481
| null | null |
S026
|
The drug 'Warfarin' functions as an 'Anticoagulant' by inhibiting 'Vitamin_K' dependent factors.
|
["Warfarin"
|
Anticoagulant
|
Vitamin_K]
|
["IS_A(Warfarin
|
H. pylori and Peptic Ulcer Disease
|
30123482
| null | null | null | null |
S027
|
Infection with 'Helicobacter_pylori' is strongly linked to the development of 'Gastric_Ulcers'.
|
["Helicobacter_pylori"
|
Gastric_Ulcers]
|
["CAUSES(Helicobacter_pylori
|
Gastric_Ulcers)"]
|
Immunomodulatory)"
|
HAS_PROPERTY(Thalidomide,Anti-angiogenic)]
|
Repurposing Thalidomide
|
30123483
| null | null |
S028
|
The small molecule 'Thalidomide' possesses both 'Immunomodulatory' and 'Anti-angiogenic' properties.
|
["Thalidomide"
|
Immunomodulatory
|
Anti-angiogenic]
|
["HAS_PROPERTY(Thalidomide
|
Anemia)"
|
REGULATES(Erythropoietin,Anemia)]
|
Renal Anemia Pathophysiology
|
30123484
| null | null |
S029
|
'Chronic_Kidney_Disease' often leads to 'Anemia' due to reduced production of 'Erythropoietin'.
|
["Chronic_Kidney_Disease"
|
Anemia
|
Erythropoietin]
|
["CAUSES(Chronic_Kidney_Disease
|
Guidelines for Asthma Management
|
30123485
| null | null | null | null |
S030
|
Inhaled 'Corticosteroids' are the cornerstone for long-term control of persistent 'Asthma'.
|
["Corticosteroids"
|
Asthma]
|
["TREATS(Corticosteroids
|
Asthma)"]
|
Thyroid_Dysfunction)"
|
CAUSES(Iodine,Goiter)]
|
Micronutrient Deficiencies
|
30123486
| null | null |
S031
|
A lack of 'Iodine' in the diet can lead to 'Thyroid_Dysfunction' and 'Goiter'.
|
["Iodine"
|
Thyroid_Dysfunction
|
Goiter]
|
["CAUSES(Iodine
|
Direct-Acting Antivirals for HCV
|
30123487
| null | null | null | null |
S032
|
The drug 'Sofosbuvir' revolutionized the treatment of 'Hepatitis_C_Virus' infection.
|
["Sofosbuvir"
|
Hepatitis_C_Virus]
|
["TREATS(Sofosbuvir
|
Hepatitis_C_Virus)"]
|
Dietary Sodium and Blood Pressure
|
30123488
| null | null | null | null |
S033
|
Excessive consumption of 'Sodium' is a major contributor to 'Hypertension'.
|
["Sodium"
|
Hypertension]
|
["CAUSES(Sodium
|
Hypertension)"]
|
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