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5,134,561 | Comparison between thermography and fluorescein test in the detection of incompetent perforating veins. | Elem B B, Shorey B A BA, Williams K L KL | British medical journal . Vol. 4, No. 5788, 1971 Dec 11 | Incompetent perforating veins of the legs were located by dynamic thermography at 69 sites and by the fluorescein test at 31. All the sites were explored by multiple local incisions. Incompetence of the veins was determined by demonstrating retrograde blood flow through these veins when severed. Explorations of these s... | https://pubmed.ncbi.nlm.nih.gov/5134561/ | [
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5,135,250 | Clinical trial of mefruside, a new diuretic. | Auld W H WH, Murdoch W R WR | British medical journal . Vol. 4, No. 5790, 1971 Dec 25 | A controlled clinical trial of a new diuretic-mefruside-is reported, in which it was compared with frusemide in 15 normal subjects and 15 patients with fluid retention. It was found to be an effective diuretic which, in the patients, produced a significantly greater excretion of water and electrolytes than an equal dos... | https://pubmed.ncbi.nlm.nih.gov/5135250/ | [
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5,531,862 | The effect of ethyl alcohol and chlorpromazine on the response of the hand blood vessels to cold. | Downey J A JA, Frewin D B DB | British journal of pharmacology . Vol. 40, No. 3, 1970 Nov | 1. The response of hand blood flow to a measured cold stimulus was determined using venous occlusion plethysmography in normal subjects, before and after orally administered alcohol, and in patients on chlorpromazine therapy.2. The average resting hand blood flow of the patients taking chlorpromazine, as well as the co... | https://pubmed.ncbi.nlm.nih.gov/5531862/ | [
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5,539,179 | A within-patient comparison of debrisoquine and methyldopa in hypertension. | Heffernan A A, Carty A A, O'Malley K K, Bugler J J | British medical journal . Vol. 1, No. 5740, 1971 Jan 09 | In a titrated dose cross-over trial of debrisoquine and methyldopa in 38 hypertensive patients neither drug was superior in lowering supine or standing diastolic pressure with a minimum of side effects. Methyldopa caused significantly greater reduction of supine (P<0.001) and standing (P<0.02) systolic pressure but cau... | https://pubmed.ncbi.nlm.nih.gov/5539179/ | [
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5,540,117 | Comparison of the effects of chlorpromazine, dextroamphetamine and methylphenidate on the behaviour and intellectual functioning of hyperactive children. | Weiss G G, Minde K K, Douglas V V, Werry J J, Sykes D D | Canadian Medical Association journal . Vol. 104, No. 1, 1971 Jan 09 | Chlorpromazine, dextroamphetamine and methylphenidate were significantly superior to placebo in producing overall improvement in the behaviour of hyperactive children. Chlorpromazine was effective for the majority of the children, but reduced only hyperactivity, having no demonstrable effect on distractibility, aggress... | https://pubmed.ncbi.nlm.nih.gov/5540117/ | [
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5,543,994 | Myocardial infarction and deep-vein thrombosis. | Nicolaides A N AN, Kakkar V V VV, Renney J T JT, Kidner P H PH, Hutchison D C DC, Clarke M B MB | British medical journal . Vol. 1, No. 5746, 1971 Feb 20 | In a study of 52 patients admitted into the coronary intensive care unit the incidence of deep-vein thrombosis was measured with the (125)I-fibrinogen test. Of these patients 31 were eventually confirmed to be suffering from acute myocardial infarction. This preliminary study showed that in patients with a confirmed in... | https://pubmed.ncbi.nlm.nih.gov/5543994/ | [
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5,338,884 | A clinical trial of four hypnotic drugs. | le Riche W H WH, Csima A A, Dobson M M | Canadian Medical Association journal . Vol. 95, No. 7, 1966 Aug 13 | A CLINICAL TRIAL OF FOUR HYPNOTIC DRUGS WAS CARRIED OUT: Ro 4-5360, 10 mg. (Mogadon), methyprylon, 200 mg. (Noludar), Ro 4-5360, 5 mg. (Mogadon), secobarbital sodium, 100 mg. (Seconal), and a placebo. The study was on the usual double-blind basis, and all observations were made by a full-time nurse. Capsules were given... | https://pubmed.ncbi.nlm.nih.gov/5338884/ | [
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5,341,676 | Oxyphenbutazone (tandearil) in rhinoplasty. A clinical evaluation of effectiveness. | Bailey B J BJ, Nahum A M AM | California medicine . Vol. 105, No. 4, 1966 Oct | To evaluate the effectiveness of Oxyphenbutazone as an anti-inflammatory agent, a double-blind study of Oxyphenbutazone and a placebo in a group of 42 patients who had nasal cosmetic operations involving osteotomy was carried out. The observations included direct objective measurement of the width of the palpebral fiss... | https://pubmed.ncbi.nlm.nih.gov/5341676/ | [
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5,343,357 | The metabolism of orally administered L-Dopa in Parkinsonism. | Calne D B DB, Karoum F F, Ruthven C R CR, Sandler M M | British journal of pharmacology . Vol. 37, No. 1, 1969 Sep | 1. Gas-liquid chromatographic methods were used to measure urinary acidic and alcoholic metabolites of L-DOPA, which had been administered in high oral dosage to patients with postencephalitic and idiopathic Parkinsonism.2. The output of these compounds was normal before treatment. During drug therapy, large quantities... | https://pubmed.ncbi.nlm.nih.gov/5343357/ | [
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5,345,935 | Earlier diagnosis and survival in lung cancer. | Brett G Z GZ | British medical journal . Vol. 4, No. 5678, 1969 Nov 01 | In a controlled investigation the survival prospects of lung cancer in a population of men aged 40 and over who had been offered six-monthly chest radiographs over a period of three years were compared with lung cancer in a similar population without such x-ray facilities. The five-year survival rate of lung cancer in ... | https://pubmed.ncbi.nlm.nih.gov/5345935/ | [
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5,350,103 | Gastric acid secretion in patients with duodenal ulcer treated for one year with anticholinergic drugs. | Kaye M D MD, Beck P P, Rhodes J J, Sweetnam P M PM | Gut . Vol. 10, No. 10, 1969 Oct | Ninety patients with duodenal ulcer, divided randomly into three groups, were treated continuously for one year with either glycopyrronium, 1-hyoscyamine (as a sustained-release preparation) or inert tablets. Dosage with active tablets was so adjusted that the patient experienced definite but tolerable side-effects. Ba... | https://pubmed.ncbi.nlm.nih.gov/5350103/ | [
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5,354,851 | Absorption of therapeutic preparations of iron measured with a whole body counter. | Callender S T ST, Warner G T GT | British medical journal . Vol. 4, No. 5682, 1969 Nov 29 | The Oxford Whole Body Counter was used to measure absorption from various therapeutic preparations of iron in five groups of subjects. Succinic acid enhanced absorption of iron when added to a solution of ferrous fumarate, but not when given with tablets of ferrous fumarate or ferrous sulphate. Ferrous fumarate plus as... | https://pubmed.ncbi.nlm.nih.gov/5354851/ | [
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5,354,874 | Renal excretion of calcium and sodium in acute nephritis. | Wilson R J RJ | British medical journal . Vol. 4, No. 5685, 1969 Dec 20 | Hypocalciuria was found in the early stages of illness in six patients aged 12 to 30 with acute nephritis. The hypocalciuria does not appear to be due to hypocalcaemia, lowered glomerular filtration rate, or hypoparathyroidism. It is suggested that the hypocalciuria is due in part to decreased intestinal absorption of ... | https://pubmed.ncbi.nlm.nih.gov/5354874/ | [
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5,354,877 | Effect on airways resistance of prostaglandin E1 given by aerosol to healthy and asthmatic volunteers. | Cuthbert M F MF | British medical journal . Vol. 4, No. 5685, 1969 Dec 20 | The forced expiratory volume in one second (F.E.V.(1)) was measured in healthy and asthmatic volunteers and the inhalation of prostaglandin E(1) (PGE(1)) was compared with that of isoprenaline, using metered aerosols.In healthy volunteers PGE(1), either as the free acid or the neutral triethanolamine salt, did not affe... | https://pubmed.ncbi.nlm.nih.gov/5354877/ | [
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5,356,547 | Effect of drugs on urate binding to plasma proteins. | Bluestone R R, Kippen I I, Klinenberg J R JR | British medical journal . Vol. 4, No. 5683, 1969 Dec 06 | The effect of various drugs on urate binding to plasma proteins was investigated in normal subjects. Whereas allopurinol, aspirin, phenylbutazone, probenecid, and sulphinpyrazone all significantly reduced plasma urate concentrations, only aspirin, phenylbutazone, and probenecid significantly impaired urate binding. Col... | https://pubmed.ncbi.nlm.nih.gov/5356547/ | [
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5,356,549 | Proteins and insulin release: a dual role of amino-acids and intestinal hormones. | Jarrett R J RJ, Graver H J HJ, Cohen N M NM | British medical journal . Vol. 4, No. 5683, 1969 Dec 06 | In two subjects concurrent infusion of amino-acids and the hormones secretin and pancreozymin provoked much higher plasma insulin levels than did administration of amino-acids or hormones individually. It is suggested that this may be a physiological phenomenon, augmenting the release of insulin from the pancreas after... | https://pubmed.ncbi.nlm.nih.gov/5356549/ | [
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3,954,392 | Intralesional recombinant alpha-2 interferon for the treatment of patients with condyloma acuminatum or verruca plantaris. | Vance J C JC, Bart B J BJ, Hansen R C RC, Reichman R C RC, McEwen C C, Hatch K D KD, Berman B B, Tanner D J DJ | Archives of dermatology . Vol. 122, No. 3, 1986 Mar | We conducted a multicenter double-blind study comparing human recombinant intralesional alpha-2 interferon (IFN) and placebo in 237 patients with the clinical diagnosis of condyloma acuminatum or verruca plantaris. A single wart on each patient was injected with 0.1 mL containing 10(6) IU of IFN, 10(5) IU of IFN, or pl... | https://pubmed.ncbi.nlm.nih.gov/3954392/ | [
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3,954,551 | Signs and symptoms of tobacco withdrawal. | Hughes J R JR, Hatsukami D D | Archives of general psychiatry . Vol. 43, No. 3, 1986 Mar | To test the validity, magnitude, and clinical significance of the signs and symptoms of tobacco withdrawal defined by DSM-III, both observed and reported signs and symptoms were measured in 50 smokers during two days of ad lib smoking and then during the first four days of abstinence. Observer and subject ratings of th... | https://pubmed.ncbi.nlm.nih.gov/3954551/ | [
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3,954,590 | Shoulder harness traction for roentgenographic assessment of the cervical spine. | Norris C S CS, Silva W E WE, Dodson T F TF, Darrow J J | Archives of surgery (Chicago, Ill. : 1960) . Vol. 121, No. 4, 1986 Apr | We evaluated the clinical usefulness of a new shoulder traction device to facilitate a rapid complete cervical spine examination in an uncooperative patient population with multiple trauma. Forty-eight patients were randomly designated to receive the shoulder traction device or the standard technique (manual traction o... | https://pubmed.ncbi.nlm.nih.gov/3954590/ | [
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3,954,815 | Influence of tasuldine and acetylcysteine on mucociliary clearance in patients with chronic airways obstruction. | Dorow P P, Weiss T T, Felix R R, Köhler M M | Arzneimittel-Forschung . Vol. 36, No. 1, 1986 | In a single-blind intraindividual cross-over comparative study the influence of two systemic-mucolytic agents, 2-(pyridyl-3-methylthio)pyrimidine (tasuldine, HE 10004-succinate) vs. N-acetyl-L-cysteine (acetylcysteine) on the mucociliary clearance and lung function was investigated in 15 patients with chronic obstructi... | https://pubmed.ncbi.nlm.nih.gov/3954815/ | [
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3,954,834 | Alcohol enhances vitamin C excretion in the urine. | Faizallah R R, Morris A I AI, Krasner N N, Walker R J RJ | Alcohol and alcoholism (Oxford, Oxfordshire) . Vol. 21, No. 1, 1986 | Urinary ascorbic acid excretion was measured on four consecutive days in 9 normal male volunteers for 4 hr before and after drinking nothing (control), 0.58 g alcohol/kg body wt as whisky or lager or water (11./70 kg body wt). The normal reduction in ascorbic acid excretion under control conditions was abolished by dri... | https://pubmed.ncbi.nlm.nih.gov/3954834/ | [
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3,954,918 | Isoflurane and halothane for outpatient dental anaesthesia in children. | Cattermole R W RW, Verghese C C, Blair I J IJ, Jones C J CJ, Flynn P J PJ, Sebel P S PS | British journal of anaesthesia . Vol. 58, No. 4, 1986 Apr | A trial was undertaken in children to compare the use of halothane and isoflurane in outpatient dental anaesthesia. A wholly inhalation technique was chosen and nitrous oxide in oxygen was delivered from a Boyle's machine via a coaxial (Bain) breathing system and was supplemented with either halothane or isoflurane. Is... | https://pubmed.ncbi.nlm.nih.gov/3954918/ | [
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3,954,920 | Comparison of the incidence and nature of cardiac arrhythmias occurring during isoflurane or halothane anaesthesia. Studies during dental surgery. | Rodrigo M R MR, Moles T M TM, Lee P K PK | British journal of anaesthesia . Vol. 58, No. 4, 1986 Apr | Seventy-six Chinese patients aged between 15 and 30 yr, undergoing 3rd molar extraction, were randomly allocated to two groups. One group received halothane and the other isoflurane. The incidence of arrhythmia during surgery under anaesthesia with isoflurane was significantly less than with halothane. Sinus tachycardi... | https://pubmed.ncbi.nlm.nih.gov/3954920/ | [
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3,954,919 | Comparison of isoflurane and halothane in outpatient paediatric dental anaesthesia. | McAteer P M PM, Carter J A JA, Cooper G M GM, Prys-Roberts C C | British journal of anaesthesia . Vol. 58, No. 4, 1986 Apr | Isoflurane was compared with halothane as the sole supplement to anaesthesia with nitrous oxide and oxygen for outpatient dental extractions in 80 children. Induction and maintenance of anaesthesia were satisfactory with both agents, although there was a higher incidence of coughing, salivation and laryngospasm in the ... | https://pubmed.ncbi.nlm.nih.gov/3954919/ | [
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3,954,933 | Intra- and inter-individual variation in pharmacokinetics of intravenously infused amoxycillin and ampicillin to elderly volunteers. | Sjövall J J, Alván G G, Huitfeldt B B | British journal of clinical pharmacology . Vol. 21, No. 2, 1986 Feb | The purpose of this study was to investigate the disposition of two aminopenicillins and their intra- and inter-individual variation in pharmacokinetic parameters in healthy, elderly volunteers. Two groups, each of 12 active, community-dwelling volunteers between 69 and 83 years of age participated. One group was given... | https://pubmed.ncbi.nlm.nih.gov/3954933/ | [
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3,954,937 | Hypnotic activity of an imidazo-pyridine (zolpidem). | Nicholson A N AN, Pascoe P A PA | British journal of clinical pharmacology . Vol. 21, No. 2, 1986 Feb | Effects of an imidazo-pyridine (zolpidem: 10, 20 and 30 mg) on overnight sleep and on performance the next day were studied in young adults and in middle aged individuals. The young adults were used particularly as an homogenous group to establish any possible adverse effects of the drug on sleep and on performance the... | https://pubmed.ncbi.nlm.nih.gov/3954937/ | [
"Clinical Trial",
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3,954,936 | Kinetic and dynamic interaction of brotizolam and ethanol. | Scavone J M JM, Greenblatt D J DJ, Harmatz J S JS, Shader R I RI | British journal of clinical pharmacology . Vol. 21, No. 2, 1986 Feb | Thirteen healthy male volunteers ingested a single 0.25 mg dose of the thienodiazepine hypnotic, brotizolam, on two occasions: once with a typical social cocktail (containing 60 ml of vodka), and in a second trial with an 'ethanol-placebo' cocktail. Brotizolam kinetics were determined from multiple plasma concentration... | https://pubmed.ncbi.nlm.nih.gov/3954936/ | [
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3,954,967 | Use of leucocyte-poor blood components and HLA-matched-platelet donors to prevent HLA alloimmunization. | Murphy M F MF, Metcalfe P P, Thomas H H, Eve J J, Ord J J, Lister T A TA, Waters A H AH | British journal of haematology . Vol. 62, No. 3, 1986 Mar | Recent studies have shown that the incidence of alloimmunization due to repeated platelet transfusions from random donors may be reduced by the use of leucocyte-poor blood components. These results were confirmed by this study, where 16% of patients with acute leukaemia undergoing initial chemotherapy and receiving leu... | https://pubmed.ncbi.nlm.nih.gov/3954967/ | [
"Clinical Trial",
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3,955,198 | Evaluation of two new megestrol acetate tablet formulations in humans. | Gaver R C RC, Pittman K A KA, Reilly C M CM, Goodson P J PJ, Breault G O GO, Fenzl E E | Biopharmaceutics & drug disposition . Vol. 7, No. 1 | The bioequivalence of two new investigational 160 mg tablets, one containing the regular form and the other a micronized form of megestrol acetate, was determined relative to a commercially available 40 mg tablet (Megace). The tablets were administered to 24 male subjects in a three-way cross-over study, balanced for s... | https://pubmed.ncbi.nlm.nih.gov/3955198/ | [
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3,955,199 | The pharmacokinetics of oral and intravenous prenalterol in young, healthy volunteers. | Clarke A F AF, Jack D B DB, Kendall M J MJ, Smith S R SR | Biopharmaceutics & drug disposition . Vol. 7, No. 1 | The pharmacokinetics of prenalterol in healthy young volunteers after i.v. and oral dosing has been studied. There is evidence of non-linearity following the i.v. dosing. Evidence of dose-dependent pharmacokinetics following i.v. dosing has been obtained. The sustained-release formulation is very effective: almost 12 h... | https://pubmed.ncbi.nlm.nih.gov/3955199/ | [
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