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🦮 Golden Retrievers

Understanding canine hemangiosarcoma — the deadliest cancer in golden retrievers.

Hemangiosarcoma (HSA) is often detected late and standard care has not improved survival (~4-6 months) in decades. With no curative pipeline near deployment, our focus is understanding its biology and genetics — an open HSA research corpus plus the genomics analyses it enables. Anchored on the Golden Retriever Lifetime Study. HSA is a vascular-endothelial tumor (the human vascular-endothelial cancer is angiosarcoma); we study the canine disease on its own terms and make no translational claims.

📂 Datasets

grls-genomics — GRLS SNP genotypes: 3,224 dogs × 913,984 markers (PLINK/CanFam3, CC-BY-SA).
hsa-literature — HSA research corpus: 4,485 papers + 1,444 CC-BY/CC0 full-text.

🤖 Models

gr-hsa-prs — germline polygenic risk + GWAS for HSA (first real run: λ_GC=0.955, SNP-h²≈0.13).

🔗 Code

All research lives in one flagship repo: gr-hemangiosarcoma — corpus, GWAS/PRS + variant annotation, the multimodal HSA risk model, and the histopathology MIL infrastructure. GitHub org: github.com/golden-retrievers.

Research project. Not veterinary advice.